Distinctive Features of Rilmenidine Possibly Related to Its Selectivity for Imidazoline Receptors

True Ainhum: Its Distinctive and Differentiating Features.

Online Arbitration Definition and its Distinctive Features

Online arbitration is different from traditional arbitration not only because the process may be held online, but also because the core elements of its definition may be different. The differences may change online arbitration definition, however, they do not, hamper the validity of online arbitration. Online arbitration can be defined and used in a very flexible approach because of its core ad...

Structural features for functional selectivity at serotonin receptors.

Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or noncanonical signaling pathways via a phenomenon known as functional selectivity or biased signaling. We report biochemical studies showing that the hallucinogen lysergic acid diethylamide, its precursor ergotamine (ERG), and related ergolines display strong functional selectivity for β-arrestin ...

The effects of imidazoline compounds on nociception in animal pain model

The discovery of imidazoline ligands has opened up a new field of study. The investigation of imidazoline actions independent of adrenoceptors started in the mid 1980s. Imidazoline receptors are classified in several subtypes, I1, I2 and I3 binding sites. Although imidazoline sites have been the subjects of research for several years, but there is still controversy about their actions especiall...

Effect of Tizanidine, Rilmenidine, and Yohimbine on Naloxon-Induced Morphine Withdrawal Syndrome in Mice

In this study using clonidine (a mixed ?2 /I1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. Morphine-dependence was induced by administration of increasing doses of morphine in mice. After the last administration of ...